Incorporation of acetate into cephalosporin C

Incorporation of acetate into cephalosporin C.

Cephalosporin C, an antibiotic with structure (I) (Abraham & Newton, 1961; Hodgkin & Maslen, 1961), was first isolated from an impure preparation of the chemically related penicillin NJ [(D-4amino-4-carboxybutyl)penicillin] that had been obtained from the culture fluid of a Cephalosporium sp. (Newton & Abraham, 1956; Abraham & Newton, 1956). The amount of cephalosporin C produced by this organi...

Incorporation of Acetate-1-c into Lipid by Typhus Rickettsiae.

Although it has been known for some time that rickettsiae have an independent, if limited, oxidative metabolism (Bovarnick and Snyder, 1949), evidence of any synthetic activity on the part of these organisms has until recently been lacking. It was noted (Bovarnick, 1956) that they were capable through oxidative phosphorylation of forming ATP,2 a compound that appears to be a prerequisite for al...

Ara-C incorporation into DNA.

Incorporation of "C-Labeled Acetate into Lipid by Isolated Foam Cells and by Atherosclerotic Arterial Intima

The synthesis of lipid by rabbit atherosclerotic intima incubated in vitro has been investigated and compared with that of foam cells isolated from intima] lesions. In the atherosclerotic arterial intima, C-labeled acetate is readily incorporated into the lipid fraction, most of the label being found in the phospholipid and cholesterol ester fatty acid fractions. Minimal incorporation into trig...

Incorporation of Acetate-1-c14 into Lipid by Typhus Rickettsiae'

Although it has been known for some time that rickettsiae have an independent, if limited, oxidative metabolism (Bovarnick and Snyder, 1949), evidence of any synthetic activity on the part of these organisms has until recently been lacking. It was noted (Bovarnick, 1956) that they were capable through oxidative phosphorylation of forming ATP,2 a compound that appears to be a prerequisite for al...